Your browser doesn't support javascript.
loading
Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.
Schick, Ursula M; Jain, Deepti; Hodonsky, Chani J; Morrison, Jean V; Davis, James P; Brown, Lisa; Sofer, Tamar; Conomos, Matthew P; Schurmann, Claudia; McHugh, Caitlin P; Nelson, Sarah C; Vadlamudi, Swarooparani; Stilp, Adrienne; Plantinga, Anna; Baier, Leslie; Bien, Stephanie A; Gogarten, Stephanie M; Laurie, Cecelia A; Taylor, Kent D; Liu, Yongmei; Auer, Paul L; Franceschini, Nora; Szpiro, Adam; Rice, Ken; Kerr, Kathleen F; Rotter, Jerome I; Hanson, Robert L; Papanicolaou, George; Rich, Stephen S; Loos, Ruth J F; Browning, Brian L; Browning, Sharon R; Weir, Bruce S; Laurie, Cathy C; Mohlke, Karen L; North, Kari E; Thornton, Timothy A; Reiner, Alex P.
  • Schick UM; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medici
  • Jain D; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Hodonsky CJ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA.
  • Morrison JV; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Davis JP; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Brown L; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Sofer T; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Conomos MP; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Schurmann C; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • McHugh CP; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Vadlamudi S; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Stilp A; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Plantinga A; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Baier L; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, 445 North 5(th) Street, Phoenix, AZ 85004, USA.
  • Bien SA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA.
  • Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Laurie CA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA; Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Liu Y; School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
  • Auer PL; Joseph J. Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA.
  • Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA.
  • Szpiro A; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Rice K; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Kerr KF; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Hanson RL; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, 445 North 5(th) Street, Phoenix, AZ 85004, USA.
  • Papanicolaou G; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
  • Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Loos RJ; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn Sc
  • Browning BL; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Browning SR; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Weir BS; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA.
  • Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
  • Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA. Electronic address: apreiner@uw.edu.
Am J Hum Genet ; 98(2): 229-42, 2016 Feb 04.
Article en En | MEDLINE | ID: mdl-26805783
ABSTRACT
Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for admixture and family relationships. We discovered and replicated associations with five genes (ACTN1, ETV7, GABBR1-MOG, MEF2C, and ZBTB9-BAK1). Our strongest association was with Amerindian-specific variant rs117672662 (p value = 1.16 × 10(-28)) in ACTN1, a gene implicated in congenital macrothrombocytopenia. rs117672662 exhibited allelic differences in transcriptional activity and protein binding in hematopoietic cells. Our results underscore the value of diverse populations to extend insights into the allelic architecture of complex traits.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Recuento de Plaquetas / Hispánicos o Latinos / Estudios de Asociación Genética / Sitios Genéticos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Recuento de Plaquetas / Hispánicos o Latinos / Estudios de Asociación Genética / Sitios Genéticos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Año: 2016 Tipo del documento: Article