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Primary central nervous system lymphoma in daily practice and the role of autologous stem cell transplantation in relapsed disease: A retrospective multicenter study.
Erkurt, Mehmet Ali; Berber, Ilhami; Tekgündüz, Emre; Dogu, Mehmet Hilmi; Korkmaz, Serdal; Demir, Cengiz; Yilmaz, Mehmet; Akay, Olga Meltem; Pala, Cigdem; Bilen, Yusuf; Kaya, Emin; Sari, Ismail; Sencan, Mehmet; Kuku, Irfan; Altuntas, Fevzi; Dal, Mehmet Sinan; Aydogdu, Ismet.
  • Erkurt MA; Department of Hematology, Inönü University Medical Faculty, Malatya, Turkey. Electronic address: erkurtali@hotmail.com.
  • Berber I; Department of Hematology, Inönü University Medical Faculty, Malatya, Turkey.
  • Tekgündüz E; Hematology and HCT Clinic, Ankara Oncology Hospital, Ankara, Turkey.
  • Dogu MH; Department of Hematology, Pamukkale University Medical Faculty, Denizli, Turkey.
  • Korkmaz S; Hematology Division, Kayseri Trainer and Research Hospital, Kayseri, Turkey.
  • Demir C; Department of Hematology, Yüzüncü Yil University Medical Faculty, Van, Turkey.
  • Yilmaz M; Department of Hematology, Antep University Medical Faculty, Gaziantep, Turkey.
  • Akay OM; Department of Hematology, Osmangazi University Medical Faculty, Eskisehir, Turkey.
  • Pala C; Department of Hematology, Erciyes University Medical Faculty, Kayseri, Turkey.
  • Bilen Y; Department of Hematology, Atatürk University Medical Faculty, Erzurum, Turkey.
  • Kaya E; Department of Hematology, Inönü University Medical Faculty, Malatya, Turkey.
  • Sari I; Department of Hematology, Pamukkale University Medical Faculty, Denizli, Turkey.
  • Sencan M; Department of Hematology, Cumhuriyet University Medical Faculty, Sivas, Turkey.
  • Kuku I; Department of Hematology, Inönü University Medical Faculty, Malatya, Turkey.
  • Altuntas F; Hematology and HCT Clinic, Ankara Oncology Hospital, Ankara, Turkey; Department of Internal Medicine, Division of Hematology, Yildirim Beyazit University Medical Faculty, Ankara, Turkey.
  • Dal MS; Hematology and HCT Clinic, Ankara Oncology Hospital, Ankara, Turkey.
  • Aydogdu I; Department of Hematology, Celal Bayar University Medical Faculty, Manisa, Turkey.
Transfus Apher Sci ; 54(1): 80-4, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26810141
ABSTRACT
We investigated the course of 54 patients presenting with primary central nervous system lymphoma, who were treated in daily practice. The patients were treated with chemotherapy and/or radiotherapy and/or intrathecal chemotherapy. At a median follow-up period of 23 months (range 1-71), median relapse-free survival (RFS) and overall survival (OS) were not reached. Estimated 2-year RFS and OS rates were 42% and 48%, respectively. Ten relapsed PCNSL patients underwent ASCT. Complete remission rate of these patients was 40%, with 20% treatment-related mortality. Estimated 2-year RFS and OS rates were 37% and 40%, respectively. The prognosis of patients with PCNSL, who received off-study treatment, is still dismal.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pautas de la Práctica en Medicina / Neoplasias del Sistema Nervioso Central / Trasplante de Células Madre / Linfoma Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pautas de la Práctica en Medicina / Neoplasias del Sistema Nervioso Central / Trasplante de Células Madre / Linfoma Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Año: 2016 Tipo del documento: Article