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Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
Boezio, Alessandro A; Copeland, Katrina W; Rex, Karen; K Albrecht, Brian; Bauer, David; Bellon, Steven F; Boezio, Christiane; Broome, Martin A; Choquette, Deborah; Coxon, Angela; Dussault, Isabelle; Hirai, Satoko; Lewis, Richard; Lin, Min-Hwa Jasmine; Lohman, Julia; Liu, Jingzhou; Peterson, Emily A; Potashman, Michele; Shimanovich, Roman; Teffera, Yohannes; Whittington, Douglas A; Vaida, Karina R; Harmange, Jean-Christophe.
  • Boezio AA; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Copeland KW; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Rex K; Amgen Incorporated , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • K Albrecht B; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Bauer D; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Bellon SF; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Boezio C; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Broome MA; Amgen Incorporated , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Choquette D; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Coxon A; Amgen Incorporated , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Dussault I; Amgen Incorporated , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Hirai S; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Lewis R; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Lin MH; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Lohman J; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Liu J; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Peterson EA; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Potashman M; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Shimanovich R; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Teffera Y; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Whittington DA; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Vaida KR; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Harmange JC; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
J Med Chem ; 59(6): 2328-42, 2016 Mar 24.
Article en En | MEDLINE | ID: mdl-26812066
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridonas / Triazoles / Proteínas Proto-Oncogénicas c-met / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridonas / Triazoles / Proteínas Proto-Oncogénicas c-met / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article