Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems.

Thevenet, Jonathan; De Marchi, Umberto; Domingo, Jaime Santo; Christinat, Nicolas; Bultot, Laurent; Lefebvre, Gregory; Sakamoto, Kei; Descombes, Patrick; Masoodi, Mojgan; Wiederkehr, Andreas

Thevenet, Jonathan; De Marchi, Umberto; Domingo, Jaime Santo; Christinat, Nicolas; Bultot, Laurent; Lefebvre, Gregory; Sakamoto, Kei; Descombes, Patrick; Masoodi, Mojgan; Wiederkehr, Andreas.

Thevenet J; Mitochondrial Function, Nestlé Institute of Health Sciences, Lausanne, Switzerland;
De Marchi U; Mitochondrial Function, Nestlé Institute of Health Sciences, Lausanne, Switzerland;
Domingo JS; Mitochondrial Function, Nestlé Institute of Health Sciences, Lausanne, Switzerland;
Christinat N; Lipid Biology, Nestlé Institute of Health Sciences, Lausanne, Switzerland;
Bultot L; Diabetes and Circadian Rhythms, Nestlé Institute of Health Sciences, Lausanne, Switzerland; and.
Lefebvre G; Functional Genomics, Nestlé Institute of Health Sciences, Lausanne, Switzerland.
Sakamoto K; Diabetes and Circadian Rhythms, Nestlé Institute of Health Sciences, Lausanne, Switzerland; and.
Descombes P; Functional Genomics, Nestlé Institute of Health Sciences, Lausanne, Switzerland.
Masoodi M; Lipid Biology, Nestlé Institute of Health Sciences, Lausanne, Switzerland;
Wiederkehr A; Mitochondrial Function, Nestlé Institute of Health Sciences, Lausanne, Switzerland; andreas.wiederkehr@rd.nestle.com.

FASEB J ; 30(5): 1913-26, 2016 05.

Article en En | MEDLINE | ID: mdl-26839375

Asunto(s)

Astrocitos/fisiología; Ácidos Grasos/farmacología; Cuerpos Cetónicos/metabolismo; Ácido Láctico/metabolismo; Mitocondrias/metabolismo; Neuronas/metabolismo; Adenosina Trifosfato/biosíntesis; Células Cultivadas; Glucólisis; Humanos; Oxidación-Reducción; Consumo de Oxígeno; Células Madre Pluripotentes; ARN Mensajero/genética; ARN Mensajero/metabolismo

Palabras clave

NAD(P)H; energy metabolism; iPSC; medium-chain triglycerides

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Astrocitos / Ácido Láctico / Ácidos Grasos / Cuerpos Cetónicos / Mitocondrias / Neuronas Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article

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