The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment.
Trends Immunol
; 37(3): 208-220, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26858199
ABSTRACT
Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor microenvironment. The main feature of these cells is their potent immune suppressive activity. MDSC are generated in the bone marrow and, in tumor-bearing hosts, migrate to peripheral lymphoid organs and the tumor to contribute to the formation of the tumor microenvironment. Recent findings have revealed differences in the function and fate of MDSC in the tumor and peripheral lymphoid organs. We review these findings here and, in this context, we discuss the current understanding as to the nature of these differences, the underlying mechanisms, and their potential impact on the regulation of tumor progression.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Supresoras de Origen Mieloide
/
Macrófagos
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article