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Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells.
Shingu, Takashi; Holmes, Lindsay; Henry, Verlene; Wang, Qianghu; Latha, Khatri; Gururaj, Anupama E; Gibson, Laura A; Doucette, Tiffany; Lang, Frederick F; Rao, Ganesh; Yuan, Liang; Sulman, Erik P; Farrell, Nicholas P; Priebe, Waldemar; Hess, Kenneth R; Wang, Yaoqi A; Hu, Jian; Bögler, Oliver.
  • Shingu T; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. tshingu@mdanderson.org.
  • Holmes L; Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, 1881 East Road, Houston, TX, 77054, USA. tshingu@mdanderson.org.
  • Henry V; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. lindsay.holmes@bcm.edu.
  • Wang Q; Baylor College of Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, USA. lindsay.holmes@bcm.edu.
  • Latha K; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. vkhenry@mdanderson.org.
  • Gururaj AE; Department of Bioinformatics and Computational Biology, The University of Texas M. D. Anderson Cancer Center, 1881 East Road, Houston, TX, 77054, USA. QWang5@mdanderson.org.
  • Gibson LA; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. QWang5@mdanderson.org.
  • Doucette T; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. klatha@mdanderson.org.
  • Lang FF; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. Anupama.E.Gururaj@uth.tmc.edu.
  • Rao G; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. lagibson@mdanderson.org.
  • Yuan L; Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, 1881 East Road, Houston, TX, 77054, USA. lagibson@mdanderson.org.
  • Sulman EP; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. tifslater@hotmail.com.
  • Farrell NP; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. flang@mdanderson.org.
  • Priebe W; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. grao@mdanderson.org.
  • Hess KR; Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, 1881 East Road, Houston, TX, 77054, USA. LYuan3@mdanderson.org.
  • Wang YA; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. EPSulman@mdanderson.org.
  • Hu J; Department of Chemistry, Virginia Commonwealth University, 901 West Franklin Street, Richmond, VA, 23284-9005, USA. npfarrell@vcu.edu.
  • Bögler O; Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1881 East Road, Houston, TX, 77054, USA. wpriebe@mdanderson.org.
J Transl Med ; 14: 46, 2016 Feb 09.
Article en En | MEDLINE | ID: mdl-26861698
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Quinasas de Proteína Quinasa Activadas por Mitógenos / Quinasas raf / Inhibidores de Proteínas Quinasas / Inhibidores de las Quinasa Fosfoinosítidos-3 / Glioma Límite: Animals / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Quinasas de Proteína Quinasa Activadas por Mitógenos / Quinasas raf / Inhibidores de Proteínas Quinasas / Inhibidores de las Quinasa Fosfoinosítidos-3 / Glioma Límite: Animals / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article