Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.

Goldsworthy, Michelle; Bai, Ying; Li, Chi-Ming; Ge, Huanying; Lamas, Edwin; Hilton, Helen; Esapa, Christopher T; Baker, Dan; Baron, Will; Juan, Todd; Véniant, Murielle M; Lloyd, David J; Cox, Roger D

Goldsworthy, Michelle; Bai, Ying; Li, Chi-Ming; Ge, Huanying; Lamas, Edwin; Hilton, Helen; Esapa, Christopher T; Baker, Dan; Baron, Will; Juan, Todd; Véniant, Murielle M; Lloyd, David J; Cox, Roger D.

Goldsworthy M; Diabetes Group, Medical Research Council Harwell, Oxfordshire, U.K. m.goldsworthy@har.mrc.ac.uk.
Bai Y; Diabetes Group, Medical Research Council Harwell, Oxfordshire, U.K.
Li CM; Genome Analysis Unit, Amgen Inc., Thousand Oaks, CA.
Ge H; Genome Analysis Unit, Amgen Inc., Thousand Oaks, CA.
Lamas E; Genome Analysis Unit, Amgen Inc., Thousand Oaks, CA.
Hilton H; Protein Core Facility, Medical Research Council Harwell, Oxfordshire, U.K.
Esapa CT; Protein Core Facility, Medical Research Council Harwell, Oxfordshire, U.K.
Baker D; Genome Analysis Unit, Amgen Inc., Thousand Oaks, CA.
Baron W; Genome Analysis Unit, Amgen Inc., Thousand Oaks, CA.
Juan T; Genome Analysis Unit, Amgen Inc., Thousand Oaks, CA.
Véniant MM; Department of Metabolic Disorders, Amgen Inc., Thousand Oaks, CA.
Lloyd DJ; Department of Metabolic Disorders, Amgen Inc., Thousand Oaks, CA.
Cox RD; Diabetes Group, Medical Research Council Harwell, Oxfordshire, U.K. r.cox@har.mrc.ac.uk.

Diabetes ; 65(5): 1434-46, 2016 05.

Article en En | MEDLINE | ID: mdl-26868295

Asunto(s)

Diabetes Mellitus Tipo 2/genética; Modelos Animales de Enfermedad; Haploinsuficiencia; Mutación; Proteína Fosfatasa 2/genética; Sitios de Empalme de ARN; Receptor de Insulina/genética; Alelos; Empalme Alternativo; Animales; Línea Celular; Diabetes Mellitus Tipo 2/sangre; Diabetes Mellitus Tipo 2/metabolismo; Diabetes Mellitus Tipo 2/fisiopatología; Progresión de la Enfermedad; Heterocigoto; Resistencia a la Insulina; Masculino; Ratones; Ratones Mutantes; Proteína Fosfatasa 2/antagonistas & inhibidores; Proteína Fosfatasa 2/metabolismo; Interferencia de ARN; ARN Interferente Pequeño; Receptor de Insulina/metabolismo; Transducción de Señal

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor de Insulina / Sitios de Empalme de ARN / Diabetes Mellitus Tipo 2 / Modelos Animales de Enfermedad / Proteína Fosfatasa 2 / Haploinsuficiencia / Mutación Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article

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