Kimura's disease: risk factors of recurrence and prognosis.
Int J Clin Exp Med
; 8(11): 21414-20, 2015.
Article
en En
| MEDLINE
| ID: mdl-26885085
ABSTRACT
OBJECTIVES:
The aim of this study was to evaluate risk factors for recurrence and prognosis of Kimura's disease.METHODS:
In this study, 32 patients received surgery alone, surgery followed by steroids orally and surgery followed by radiotherapy respectively from 2003 to 2015 (male/female 27/5, ages 6-64 years). Retrieval of clinical data and follow-ups have been done. The clinical features used as variables include age, gender, location, multiplicity, laterality, size, duration, primary outbreak, smoking, eosinophils, systemic disease and remedies. Statistical analysis including Kaplan-Meier method, Fisher's exact test, Kruskal-Wallis H test, Mann-Whitney U-test and Cox proportional hazard regression model were performed with the SPSS 17.0. The threshold of statistical significance was set at P=0.05.RESULTS:
Median recurrence time was 29 months (2.42 years) after discharged and 56.3% patients relapsed. High recurrence rate was significantly associated with smoking habit (P=0.036). Patients who were diagnosed systemic disease (P=0.027) and were treated with surgery alone (P=0.025) or surgery followed by steroids orally (P=0.025) had short disease-free time. Furthermore, smoking habit (HR=3.383, 95% CI 1.213-9.433, P=0.02), systemic disease (HR=4.462, 95% CI 1.443-13.794, P=0.009), surgery alone (HR=4.668, 95% CI 1.506-14.470, P=0.008) and surgery followed by steroids orally (HR=6.053, 95% CI 1.330-27.556, P=0.02) were identified as risk factors for the prognosis of Kimura's disease.CONCLUSIONS:
Smoking habit, systemic diseases, surgery alone and surgery followed by steroids orally were associated with poor prognosis of Kimura's disease, and they might be prognostic markers of Kimura's disease.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Año:
2015
Tipo del documento:
Article