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Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design.
Maass, Katie F; Kulkarni, Chethana; Betts, Alison M; Wittrup, K Dane.
  • Maass KF; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Kulkarni C; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Betts AM; Oncology Medicinal Chemistry, Worldwide Medicinal Chemistry, Pfizer, Groton, Connecticut, USA.
  • Wittrup KD; Translational Research Group, Department of Pharmacokinetics Dynamics and Metabolism, Pfizer, Groton, Connecticut, USA.
AAPS J ; 18(3): 635-46, 2016 05.
Article en En | MEDLINE | ID: mdl-26912181
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Membrana Celular / Anticuerpos Monoclonales Humanizados / Trastuzumab / Maitansina / Antineoplásicos Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Membrana Celular / Anticuerpos Monoclonales Humanizados / Trastuzumab / Maitansina / Antineoplásicos Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article