Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents.

Desai, N C; Somani, Hardik; Trivedi, Amit; Bhatt, Kandarp; Nawale, Laxman; Khedkar, Vijay M; Jha, Prakash C; Sarkar, Dhiman

Desai, N C; Somani, Hardik; Trivedi, Amit; Bhatt, Kandarp; Nawale, Laxman; Khedkar, Vijay M; Jha, Prakash C; Sarkar, Dhiman.

Desai NC; Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364 002, Gujarat, India. Electronic address: dnisheeth@rediffmail.com.
Somani H; Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364 002, Gujarat, India.
Trivedi A; Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364 002, Gujarat, India.
Bhatt K; Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364 002, Gujarat, India.
Nawale L; Combi Chem Bio Resource Centre, National Chemical Laboratory, Pune 411 008, India.
Khedkar VM; Combi Chem Bio Resource Centre, National Chemical Laboratory, Pune 411 008, India.
Jha PC; School of Chemical Sciences, Central University of Gujarat, Sector-30, Gandhinagar 382 030, Gujarat, India.
Sarkar D; Combi Chem Bio Resource Centre, National Chemical Laboratory, Pune 411 008, India.

Bioorg Med Chem Lett ; 26(7): 1776-83, 2016 Apr 01.

Article en En | MEDLINE | ID: mdl-26920799

Asunto(s)

Antituberculosos/química; Antituberculosos/farmacología; Mycobacterium bovis/efectos de los fármacos; Mycobacterium tuberculosis/efectos de los fármacos; Oxadiazoles/química; Oxadiazoles/farmacología; Animales; Línea Celular; Humanos; Indoles/química; Indoles/farmacología; Pruebas de Sensibilidad Microbiana; Simulación del Acoplamiento Molecular; Mycobacterium bovis/enzimología; Mycobacterium tuberculosis/enzimología; Piridinas/química; Piridinas/farmacología; Relación Estructura-Actividad; Tuberculosis/tratamiento farmacológico; Tuberculosis/microbiología; Tuberculosis/veterinaria

Palabras clave

1,3,4-Oxadiazole; Antitubercular activity; Cytotoxicity; Indole; Molecular docking; Pyridine

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxadiazoles / Mycobacterium bovis / Mycobacterium tuberculosis / Antituberculosos Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article

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