Estimate of anti-Plasmodium falciparum sporozoite activity in humans vaccinated with synthetic circumsporozoite protein (NANP)3.
Trans R Soc Trop Med Hyg
; 83(6): 748-50, 1989.
Article
en En
| MEDLINE
| ID: mdl-2694506
ABSTRACT
A mathematical model was defined to estimate the degree of in vivo activity against Plasmodium falciparum sporozoites expressed by volunteers vaccinated with a synthetic peptide comprising the immunodominant epitope of the circumsporozoite protein. Relative to the course of infection in non-immunized controls, infections in vaccinated volunteers corresponded to the neutralization or delay of development of greater than 99% of challenge sporozoites.
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Banco de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Plasmodium falciparum
/
Malaria
Límite:
Animals
/
Humans
Idioma:
En
Año:
1989
Tipo del documento:
Article