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Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Fairhurst, Robin A; Marsilje, Thomas H; Stutz, Stefan; Boos, Andreas; Niklaus, Michel; Chen, Bei; Jiang, Songchun; Lu, Wenshuo; Furet, Pascal; McCarthy, Clive; Stauffer, Frédéric; Guagnano, Vito; Vaupel, Andrea; Michellys, Pierre-Yves; Schnell, Christian; Jeay, Sébastien.
  • Fairhurst RA; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland. Electronic address: robin.fairhurst@novartis.com.
  • Marsilje TH; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
  • Stutz S; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Boos A; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Niklaus M; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Chen B; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
  • Jiang S; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
  • Lu W; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
  • Furet P; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • McCarthy C; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Stauffer F; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Guagnano V; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Vaupel A; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Michellys PY; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
  • Schnell C; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
  • Jeay S; Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
Bioorg Med Chem Lett ; 26(8): 2057-64, 2016 Apr 15.
Article en En | MEDLINE | ID: mdl-26951753
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazinas / Pirimidinas / Pirroles / Receptor IGF Tipo 1 / Inhibidores de Proteínas Quinasas / Imidazoles / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazinas / Pirimidinas / Pirroles / Receptor IGF Tipo 1 / Inhibidores de Proteínas Quinasas / Imidazoles / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article