Your browser doesn't support javascript.
loading
Soluble biomarkers development in osteoarthritis: from discovery to personalized medicine.
Henrotin, Yves; Sanchez, Christelle; Cornet, Anne; Van de Put, Joachim; Douette, Pierre; Gharbi, Myriam.
  • Henrotin Y; a Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Institute of Pathology , CHU Sart-Tilman , Liège , Belgium .
  • Sanchez C; b Department of Physical Therapy and Rehabilitation , Princess Paola Hospital , Marche-en-Famenne , Belgium .
  • Cornet A; c GIGA Tower , Liège , Belgium , and.
  • Van de Put J; d Synolyne Pharma , Herstal , Belgium.
  • Douette P; a Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Institute of Pathology , CHU Sart-Tilman , Liège , Belgium .
  • Gharbi M; c GIGA Tower , Liège , Belgium , and.
Biomarkers ; 20(8): 540-6, 2015.
Article en En | MEDLINE | ID: mdl-26954785
ABSTRACT
CONTEXT Specific soluble biomarkers could be a precious tool for diagnosis, prognosis and personalized management of osteoarthritic (OA) patients.

OBJECTIVE:

To describe the path of soluble biomarker development from discovery to clinical qualification and regulatory adoption toward OA-related biomarker qualification. METHODS AND

RESULTS:

This review summarizes current guidance on the use of biomarkers in OA in clinical trials and their utility at five stages, including preclinical development and phase 1 to phase 4 trials. It also presents all the available regulatory requirements.

CONCLUSIONS:

The path through the adoption of a specific soluble biomarker for OA is steep but is worth the challenge due to the benefit that it can provide.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Osteoartritis / Biomarcadores / Medicina de Precisión Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Osteoartritis / Biomarcadores / Medicina de Precisión Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2015 Tipo del documento: Article