Reproductive and genital health and risk of cervical human papillomavirus infection: results from the Ludwig-McGill cohort study.
BMC Infect Dis
; 16: 116, 2016 Mar 08.
Article
en En
| MEDLINE
| ID: mdl-26956880
ABSTRACT
BACKGROUND:
There are inconsistencies in the literature on reproductive and genital health determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer. We examined these factors in the Ludwig-McGill Cohort Study, a longitudinal, repeated-measurements investigation on the natural history of HPV infection.METHODS:
We analyzed a cohort subset of 1867 women with one complete year of follow-up. We calculated odds ratios (OR) and 95% confidence intervals (CI) for reproductive and genital health characteristics from questionnaire and laboratory data in relation to 1-year period prevalence of HPV infection. Two outcomes were measured; the first based on phylogenetic grouping of HPV types based on tissue tropism and oncogenicity (Alphapapillomavirus Subgenus 1 species 1, 8, 10 and 13; Subgenus 2 species 5, 6, 7, 9, 11; Subgenus 3 species 3, 4 and 14) and the second based on transient or persistent HPV infections.RESULTS:
Lifetime (Subgenus 3 OR = 2.00, CI 1.23-3.24) and current (Subgenus 3 OR =2.00, CI 1.15-3.47) condom use and use of contraceptive injections (Subgenus 1 OR = 1.96, CI 1.22-3.16, Subgenus 2 OR = 1.34, CI 1.00-1.79) were associated with increased risk of HPV infection. Intrauterine device use was protective (Subgenus 1 OR = 0.48, CI 0.30-0.75, Subgenus 2 OR = 0.78, CI 0.62-0.98). These factors were not associated with persistence of HPV infection. Tampon use, previous gynecologic infections and cervical inflammation were associated with an overall increased risk of HPV infection.CONCLUSIONS:
Cervical HPV infection was associated with reproductive and genital health factors. Further studies are necessary to confirm the low to moderate associations observed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Cuello Uterino
/
Infecciones por Papillomavirus
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Middle aged
País como asunto:
America do sul
/
Brasil
Idioma:
En
Año:
2016
Tipo del documento:
Article