G9a-mediated methylation of ER&#945; links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.

Zhang, Xi; Peng, Danni; Xi, Yuanxin; Yuan, Chao; Sagum, Cari A; Klein, Brianna J; Tanaka, Kaori; Wen, Hong; Kutateladze, Tatiana G; Li, Wei; Bedford, Mark T; Shi, Xiaobing

G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.

Zhang, Xi; Peng, Danni; Xi, Yuanxin; Yuan, Chao; Sagum, Cari A; Klein, Brianna J; Tanaka, Kaori; Wen, Hong; Kutateladze, Tatiana G; Li, Wei; Bedford, Mark T; Shi, Xiaobing.

Zhang X; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Peng D; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Xi Y; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Yuan C; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Sagum CA; Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Klein BJ; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Tanaka K; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Wen H; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Kutateladze TG; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Li W; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Shi X; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Nat Commun ; 7: 10810, 2016 Mar 10.

Article en En | MEDLINE | ID: mdl-26960573

Asunto(s)

Antígenos de Neoplasias/genética; Biomarcadores de Tumor/genética; Neoplasias de la Mama/genética; Epigénesis Genética; Receptor alfa de Estrógeno/genética; Regulación Neoplásica de la Expresión Génica; Antígenos de Histocompatibilidad/genética; Histona Acetiltransferasas/genética; N-Metiltransferasa de Histona-Lisina/genética; Acetilación; Antígenos de Neoplasias/metabolismo; Biomarcadores de Tumor/metabolismo; Línea Celular Tumoral; Proteínas de Unión al ADN; Receptor alfa de Estrógeno/metabolismo; Femenino; Técnica del Anticuerpo Fluorescente; Células HEK293; Antígenos de Histocompatibilidad/metabolismo; Histona Acetiltransferasas/metabolismo; N-Metiltransferasa de Histona-Lisina/metabolismo; Humanos; Inmunoprecipitación; Técnicas In Vitro; Células MCF-7; Espectroscopía de Resonancia Magnética; Coactivador 2 del Receptor Nuclear; Regiones Promotoras Genéticas; Reacción en Cadena en Tiempo Real de la Polimerasa; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Factores de Transcripción

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / N-Metiltransferasa de Histona-Lisina / Epigénesis Genética / Receptor alfa de Estrógeno / Histona Acetiltransferasas / Antígenos de Histocompatibilidad / Antígenos de Neoplasias Límite: Female / Humans Idioma: En Año: 2016 Tipo del documento: Article

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