Weight Loss Predicts Progression of Mild Cognitive Impairment to Alzheimer's Disease.
PLoS One
; 11(3): e0151710, 2016.
Article
en En
| MEDLINE
| ID: mdl-26990757
ABSTRACT
BACKGROUND:
Weight loss is common in people with Alzheimer's disease (AD) and it could be a marker of impending AD in Mild Cognitive Impairment (MCI) and improve prognostic accuracy, if accelerated progression to AD would be shown.AIMS:
To assess weight loss as a predictor of dementia and AD in MCI.METHODS:
One hundred twenty-five subjects with MCI (age 73.8 ± 7.1 years) were followed for an average of 4 years. Two weight measurements were carried out at a minimum time interval of one year. Dementia was defined according to DSM-IV criteria and AD according to NINCDS-ADRDA criteria. Weight loss was defined as a ≥4% decrease in baseline weight.RESULTS:
Fifty-three (42.4%) MCI progressed to dementia, which was of the AD-type in half of the cases. Weight loss was associated with a 3.4-fold increased risk of dementia (95% CI = 1.5-6.9) and a 3.2-fold increased risk of AD (95% CI = 1.4-8.3). In terms of years lived without disease, weight loss was associated to a 2.3 and 2.5 years earlier onset of dementia and AD.CONCLUSIONS:
Accelerated progression towards dementia and AD is expected when weight loss is observed in MCI patients. Weight should be closely monitored in elderly with mild cognitive impairment.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Demencia Vascular
/
Pérdida de Peso
/
Enfermedad por Cuerpos de Lewy
/
Enfermedad de Alzheimer
/
Disfunción Cognitiva
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
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Humans
/
Male
Idioma:
En
Año:
2016
Tipo del documento:
Article