Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4R&#945; overexpressed melanoma models.

Lee, Hye Lim; Park, Mi Hee; Song, Ju Kyoung; Jung, Yu Yeon; Kim, Youngsoo; Kim, Kyung Bo; Hwang, Dae Yeon; Yoon, Do Young; Song, Min Jong; Han, Sang Bae; Hong, Jin Tae

Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models.

Lee, Hye Lim; Park, Mi Hee; Song, Ju Kyoung; Jung, Yu Yeon; Kim, Youngsoo; Kim, Kyung Bo; Hwang, Dae Yeon; Yoon, Do Young; Song, Min Jong; Han, Sang Bae; Hong, Jin Tae.

Lee HL; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, 361-951, Republic of Korea.
Park MH; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, 361-951, Republic of Korea.
Song JK; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, 361-951, Republic of Korea.
Jung YY; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, 361-951, Republic of Korea.
Kim Y; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, 361-951, Republic of Korea.
Kim KB; Department of Pharmaceutical Science, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.
Hwang DY; Department of Biomaterial Science, Pusan National University, Miryang, Kyungnam, 627-706, Republic of Korea.
Yoon do Y; Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Gwangjin-gu, Seoul, 143-701, Republic of Korea.
Song MJ; Department of Obstetrics and Gynecology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Jung-gu, Daejeon, 301-723, Republic of Korea.
Han SB; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, 361-951, Republic of Korea.
Hong JT; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, 361-951, Republic of Korea.

Oncotarget ; 7(17): 23425-38, 2016 Apr 26.

Article en En | MEDLINE | ID: mdl-26993600

Asunto(s)

Biomarcadores de Tumor/metabolismo; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Subunidad alfa del Receptor de Interleucina-4/metabolismo; Interleucina-4/metabolismo; Melanoma/patología; Factor de Transcripción STAT6/metabolismo; Animales; Apoptosis; Biomarcadores de Tumor/genética; Proliferación Celular; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/genética; Modelos Animales de Enfermedad; Femenino; Humanos; Interleucina-4/genética; Subunidad alfa del Receptor de Interleucina-4/genética; Masculino; Melanoma/genética; Melanoma/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Endogámicos DBA; Ratones Transgénicos; Pronóstico; Factor de Transcripción STAT6/genética; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

IL-4; STAT6; melanoma; p21; tumor growth

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Interleucina-4 / Factor de Transcripción STAT6 / Inhibidor p21 de las Quinasas Dependientes de la Ciclina / Subunidad alfa del Receptor de Interleucina-4 / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article

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