A pepducin designed to modulate P2Y2R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk mechanism.

Gabl, Michael; Holdfeldt, André; Winther, Malene; Oprea, Tudor; Bylund, Johan; Dahlgren, Claes; Forsman, Huamei

Gabl, Michael; Holdfeldt, André; Winther, Malene; Oprea, Tudor; Bylund, Johan; Dahlgren, Claes; Forsman, Huamei.

Gabl M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Holdfeldt A; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Winther M; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Oprea T; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Translational Informatics Division, UNM Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Bylund J; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Dahlgren C; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address: Claes.Dahlgren@microbio.gu.se.
Forsman H; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.

Biochim Biophys Acta ; 1863(6 Pt A): 1228-37, 2016 Jun.

Article en En | MEDLINE | ID: mdl-26996596

Asunto(s)

Adenosina Trifosfato/metabolismo; NADPH Oxidasas/metabolismo; Neutrófilos/metabolismo; Péptidos/metabolismo; Receptores de Formil Péptido/metabolismo; Receptores de Lipoxina/metabolismo; Receptores Purinérgicos P2Y2/metabolismo; Secuencia de Aminoácidos; Unión Competitiva/efectos de los fármacos; Calcio/metabolismo; Células Cultivadas; Células HL-60; Humanos; Ligandos; Datos de Secuencia Molecular; Neutrófilos/citología; Neutrófilos/efectos de los fármacos; Oxígeno/metabolismo; Péptidos/farmacología; Unión Proteica/efectos de los fármacos; Receptor Cross-Talk/efectos de los fármacos; Receptores Purinérgicos P2Y2/química; Factores de Tiempo

Palabras clave

FPRs; Inflammation; Neutrophils; P2Y(2)R; Pepducins

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos / Adenosina Trifosfato / NADPH Oxidasas / Receptores de Lipoxina / Receptores de Formil Péptido / Receptores Purinérgicos P2Y2 / Neutrófilos Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google