Candidatus Rickettsia tarasevichiae Infection in Eastern Central China: A Case Series.
Ann Intern Med
; 164(10): 641-8, 2016 05 17.
Article
en En
| MEDLINE
| ID: mdl-27019406
ABSTRACT
BACKGROUND:
Human infection with Candidatus Rickettsia tarasevichiae (CRT) was first reported in northeastern China in 2012.OBJECTIVE:
To describe the clinical spectrum and laboratory findings of patients infected with CRT in eastern central China.DESIGN:
Case series.SETTING:
A sentinel hospital for severe fever with thrombocytopenia syndrome (SFTS) in eastern central China in 2014.PARTICIPANTS:
Hospitalized patients with SFTS-like illness. MEASUREMENTS Molecular and serologic tests were performed to diagnose CRT infection. Data about clinical manifestations and laboratory findings were retrieved from medical records.RESULTS:
56 of 733 assessed patients had CRT based on polymerase chain reaction and sequencing. All patients presented with nonspecific manifestations, including fever (96%), malaise (88%), myalgia (57%), cough (25%), and dizziness (14%). Only 2 patients had rash. Further, 16% had eschar, 29% had lymphadenopathy, 100% had gastrointestinal symptoms, 34% had neurologic symptoms, 43% had hemorrhagic manifestations, and 23% had signs of plasma leakage. Thrombocytopenia was observed in 70%, leukopenia in 59%; lymphopenia in 45%; and elevated levels of lactate dehydrogenase in 82%, aspartate aminotransferase in 70%, alanine aminotransferase in 54%, and creatinine kinase in 46%. Co-infection with SFTS virus was documented in 66% patients, and 8 of the 56 patients died.LIMITATIONS:
Patients with CRT were not treated for infection because they were retrospectively identified. This was not a population-based study, and the results cannot be generalized to all patients with CRT.CONCLUSION:
Candidatus R tarasevichiae infection should be considered in the differential diagnosis of febrile patients with SFTS-like illness in endemic areas. PRIMARY FUNDING SOURCE National Natural Science Foundation of China.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Rickettsia
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Infecciones por Rickettsia
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Infección Hospitalaria
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País como asunto:
Asia
Idioma:
En
Año:
2016
Tipo del documento:
Article