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Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.
Zhou, Zinan; Tang, Alan T; Wong, Weng-Yew; Bamezai, Sharika; Goddard, Lauren M; Shenkar, Robert; Zhou, Su; Yang, Jisheng; Wright, Alexander C; Foley, Matthew; Arthur, J Simon C; Whitehead, Kevin J; Awad, Issam A; Li, Dean Y; Zheng, Xiangjian; Kahn, Mark L.
  • Zhou Z; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA.
  • Tang AT; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA.
  • Wong WY; Laboratory of Cardiovascular Signaling, Centenary Institute, Sydney, New South Wales 2050, Australia.
  • Bamezai S; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA.
  • Goddard LM; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA.
  • Shenkar R; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, Illinois 60637, USA.
  • Zhou S; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA.
  • Yang J; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA.
  • Wright AC; Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA.
  • Foley M; Sydney Microscopy &Microanalysis, University of Sydney, Sydney, New South Wales 2050, Australia.
  • Arthur JS; Division of Cell Signaling and Immunology, University of Dundee, Dundee DD1 5EH, UK.
  • Whitehead KJ; Division of Cardiovascular Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, Utah 84112, USA.
  • Awad IA; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, Illinois 60637, USA.
  • Li DY; Division of Cardiovascular Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, Utah 84112, USA.
  • Zheng X; The Key Laboratory for Human Disease Gene Study of Sichuan Province, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences &Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
  • Kahn ML; Laboratory of Cardiovascular Signaling, Centenary Institute, Sydney, New South Wales 2050, Australia.
Nature ; 532(7597): 122-6, 2016 Apr 07.
Article en En | MEDLINE | ID: mdl-27027284
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hemangioma Cavernoso del Sistema Nervioso Central / Sistema de Señalización de MAP Quinasas / Células Endoteliales / MAP Quinasa Quinasa Quinasa 3 / Factores de Transcripción de Tipo Kruppel Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hemangioma Cavernoso del Sistema Nervioso Central / Sistema de Señalización de MAP Quinasas / Células Endoteliales / MAP Quinasa Quinasa Quinasa 3 / Factores de Transcripción de Tipo Kruppel Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article