Discovery of a Novel Diterpene in Brown Propolis from the State of Parana, Brazil.
Nat Prod Commun
; 11(2): 201-5, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-27032202
ABSTRACT
Propolis is a resinous substance collected by honeybees from certain plant sources. The components of propolis depend on the vegetation of the area in which apiculture is practiced. In Brazil, there are several types of propolis including 'green,' 'red' and 'brown'. Brazilian brown propolis from the state of Parana characteristically includes diterpenes, and we discovered a novel clerodane diterpene, rel-(5S,6S,8R,9R,10S,18R,19S)-18,19-epoxy-2-oxocleroda-3,12(E),14- triene-6,18,19-triol 18,19-diacetate 6-benzoate (3) and five known diterpenes (1, 2, 4, 5 and 6). The chemical structure of the novel diterpene 3 was determined using 1D- and 2D-NMR spectroscopic analyses. Furthermore, the activities of the isolated diterpenes on growth inhibition of several human cancer cell lines (LNCaP, MCF-7, DLD-1 and A549) were evaluated in vitro; diterpene 3 exhibited a potent inhibition of cell growth, and its activity was approximately 15 times higher than that of the other diterpenes.
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Banco de datos:
MEDLINE
Asunto principal:
Própolis
/
Diterpenos de Tipo Clerodano
Límite:
Humans
País como asunto:
America do sul
/
Brasil
Idioma:
En
Año:
2016
Tipo del documento:
Article