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DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.
Joubert, Bonnie R; Felix, Janine F; Yousefi, Paul; Bakulski, Kelly M; Just, Allan C; Breton, Carrie; Reese, Sarah E; Markunas, Christina A; Richmond, Rebecca C; Xu, Cheng-Jian; Küpers, Leanne K; Oh, Sam S; Hoyo, Cathrine; Gruzieva, Olena; Söderhäll, Cilla; Salas, Lucas A; Baïz, Nour; Zhang, Hongmei; Lepeule, Johanna; Ruiz, Carlos; Ligthart, Symen; Wang, Tianyuan; Taylor, Jack A; Duijts, Liesbeth; Sharp, Gemma C; Jankipersadsing, Soesma A; Nilsen, Roy M; Vaez, Ahmad; Fallin, M Daniele; Hu, Donglei; Litonjua, Augusto A; Fuemmeler, Bernard F; Huen, Karen; Kere, Juha; Kull, Inger; Munthe-Kaas, Monica Cheng; Gehring, Ulrike; Bustamante, Mariona; Saurel-Coubizolles, Marie José; Quraishi, Bilal M; Ren, Jie; Tost, Jörg; Gonzalez, Juan R; Peters, Marjolein J; Håberg, Siri E; Xu, Zongli; van Meurs, Joyce B; Gaunt, Tom R; Kerkhof, Marjan; Corpeleijn, Eva.
  • Joubert BR; National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • Felix JF; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterda
  • Yousefi P; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
  • Bakulski KM; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
  • Just AC; Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Breton C; University of Southern California, Los Angeles, CA 90032, USA.
  • Reese SE; National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • Markunas CA; National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
  • Richmond RC; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • Xu CJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; GRIAC Research Institute Groningen, University of Gro
  • Küpers LK; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
  • Oh SS; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-2911, USA.
  • Hoyo C; Department of Biological Sciences and Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695-7633, USA.
  • Gruzieva O; Institute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden.
  • Söderhäll C; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm 141 83, Sweden.
  • Salas LA; Centre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
  • Baïz N; Sorbonne Universités, UPMC Univ Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Saint-Antoine Medical School, F75012 Paris, France.
  • Zhang H; Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.
  • Lepeule J; Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institut Albert Bonniot, Institut National de la Santé et de le Recherche Médicale, University of Grenoble Alpes, Centre Hospitalier Universitaire de Grenoble, F-38000 Grenoble, France.
  • Ruiz C; Centre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
  • Ligthart S; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands.
  • Wang T; National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • Taylor JA; National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • Duijts L; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA the Netherlands; Division of Neonatology, Department of Pediatrics, Erasmus MC, Universit
  • Sharp GC; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • Jankipersadsing SA; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
  • Nilsen RM; Department of Global Public Health and Primary Care, University of Bergen, Bergen 5018, Norway.
  • Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
  • Fallin MD; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
  • Hu D; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-2911, USA.
  • Litonjua AA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Fuemmeler BF; Department of Community and Family Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Huen K; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
  • Kere J; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm 141 83, Sweden.
  • Kull I; Institute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden.
  • Munthe-Kaas MC; Department of Pediatrics, Oslo University Hospital, Oslo 424, Norway.
  • Gehring U; Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, the Netherlands.
  • Bustamante M; Centre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain; Center for Genomic Regulation (CRG), Barcelona 08003, Spain.
  • Saurel-Coubizolles MJ; INSERM, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, 75654 Paris, France.
  • Quraishi BM; Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.
  • Ren J; University of Southern California, Los Angeles, CA 90032, USA.
  • Tost J; Laboratory for Epigenetics and Environment, Centre National de Génotypage, CEA-Institut de Génomique, 91000 Evry, France.
  • Gonzalez JR; Centre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
  • Peters MJ; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, the Netherlands.
  • Håberg SE; Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo 0403, Norway.
  • Xu Z; National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • van Meurs JB; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, the Netherlands.
  • Gaunt TR; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • Kerkhof M; GRIAC Research Institute Groningen, University of Groningen, University Medical Center Groningen, 9700 RB, the Netherlands.
  • Corpeleijn E; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Am J Hum Genet ; 98(4): 680-96, 2016 Apr 07.
Article en En | MEDLINE | ID: mdl-27040690
Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fumar / Metilación de ADN / Epigénesis Genética Tipo de estudio: Etiology_studies / Systematic_reviews Límite: Child / Child, preschool / Female / Humans / Infant / Newborn / Pregnancy Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fumar / Metilación de ADN / Epigénesis Genética Tipo de estudio: Etiology_studies / Systematic_reviews Límite: Child / Child, preschool / Female / Humans / Infant / Newborn / Pregnancy Idioma: En Año: 2016 Tipo del documento: Article