Enantioselective intramolecular cyclization of alkynyl esters catalyzed by a chiral Brønsted base.
Chem Commun (Camb)
; 52(33): 5726-9, 2016 Apr 28.
Article
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| MEDLINE
| ID: mdl-27043300
ABSTRACT
An enantioselective intramolecular cyclization reaction of alkynyl esters was developed, which employs a Brønsted base catalyst generated in situ from a chiral Schiff base and t-BuOK. This reaction is a rare example of the enantioselective intramolecular addition of simple ester enolates to alkynes under Brønsted base catalysis.
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MEDLINE
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En
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2016
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Article