Epidemiology of nontuberculous mycobacteria (NTM) amongst individuals with cystic fibrosis (CF).
J Cyst Fibros
; 15(5): 619-23, 2016 09.
Article
en En
| MEDLINE
| ID: mdl-27050794
ABSTRACT
BACKGROUND:
Infection by nontuberculous mycobacteria (NTM) in patients with cystic fibrosis (CF) is often associated with significant morbidity. Limited, conflicting results are published regarding risk factors for pulmonary NTM disease. We analysed factors potentially associated with NTM in a large population of European patients with CF.METHODS:
We investigated associations between presence of NTM and various factors for patients registered in the European Cystic Fibrosis Society Patient Registry.RESULTS:
374 (2.75%) of 13,593 patients studied had at least one positive NTM culture within the study year. Age- and FEV1-adjusted odds of NTM infection was more than 2.5 times higher (95%CI 1.79; 3.60) in patients infected by Stenotrophomonas maltophilia than in patients not infected (p<0.0001), 2.36 times higher (95%CI 1.80;3.08) in patients with ABPA than without (p<0.0001), 1.79 times higher (95%CI 1.34; 2.38) in patients who use bronchodilators than in patients who don't (p<0.0001), 1.49 times higher (95%CI 1.18; 1.89) in patients who use inhaled antibiotics than in patients who don't (p=0.001), and 1.30 times higher (95%CI 1.02; 1.66) in patients who use rhDNase than in patients who don't (p=0.032).CONCLUSIONS:
NTM-positive cultures in individuals with CF are associated with distinct clinical variables. Improved data collection identifying risk factors for NTM infection will allow more focused screening strategies, and influence therapeutic choices and infection control measures in high-risk patients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones del Sistema Respiratorio
/
Fibrosis Quística
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Micobacterias no Tuberculosas
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Infecciones por Mycobacterium no Tuberculosas
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Female
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Humans
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Male
País como asunto:
Europa
Idioma:
En
Año:
2016
Tipo del documento:
Article