Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells.
FEBS Lett
; 246(1-2): 78-82, 1989 Mar 27.
Article
en En
| MEDLINE
| ID: mdl-2707442
ABSTRACT
In this report, we demonstrate a direct correlation between protein kinase C (PKC) activity and adriamycin (ADR) resistance in mouse fibrosarcoma cells. PKC activity was measured in four murine UV-2237M fibrosarcoma cell lines that differed in the degrees to which they expressed resistance to ADR, which is an inhibitor of PKC. A comparison of the four cell lines revealed a positive correlation between the level of PKC activity and resistance to ADR. Incubation of the cells with the PKC inhibitor H-7 produced a partial reversal of ADR resistance. Taken together, these results suggest a role for PKC in the mechanism of ADR resistance.
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Banco de datos:
MEDLINE
Asunto principal:
Proteína Quinasa C
/
Doxorrubicina
/
Fibrosarcoma
Límite:
Animals
Idioma:
En
Año:
1989
Tipo del documento:
Article