Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.
Bioorg Med Chem Lett
; 26(11): 2735-8, 2016 06 01.
Article
en En
| MEDLINE
| ID: mdl-27080185
ABSTRACT
Led by the structural information of the screening hit with mDM2 protein, a structure modification of Leu26 moiety of the novel p53-hDM2 inhibitors was conducted. A structure-activity relationship study of 4-substituted piperidines revealed compound 20t with good potencies and excellent CYP450 profiles.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Proteína p53 Supresora de Tumor
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Proteínas Proto-Oncogénicas c-mdm2
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Leucina
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article