MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents.

Shah, M Y; Martinez-Garcia, E; Phillip, J M; Chambliss, A B; Popovic, R; Ezponda, T; Small, E C; Will, C; Phillip, M P; Neri, P; Bahlis, N J; Wirtz, D; Licht, J D

Shah, M Y; Martinez-Garcia, E; Phillip, J M; Chambliss, A B; Popovic, R; Ezponda, T; Small, E C; Will, C; Phillip, M P; Neri, P; Bahlis, N J; Wirtz, D; Licht, J D.

Shah MY; Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Martinez-Garcia E; Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Phillip JM; Department of Chemical and Biomolecular Engineering, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA.
Chambliss AB; Department of Chemical and Biomolecular Engineering, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA.
Popovic R; Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ezponda T; Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Small EC; Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Will C; Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Phillip MP; Department of Chemical and Biomolecular Engineering, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA.
Neri P; Departments of Oncology and Medicine, University of Calgary and Tom Baker Cancer Centre, Calgary, AB, Canada.
Bahlis NJ; Departments of Oncology and Medicine, University of Calgary and Tom Baker Cancer Centre, Calgary, AB, Canada.
Wirtz D; Department of Chemical and Biomolecular Engineering, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA.
Licht JD; Department of Oncology and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Oncogene ; 35(45): 5905-5915, 2016 11 10.

Article en En | MEDLINE | ID: mdl-27109101

Asunto(s)

Antineoplásicos/farmacología; Daño del ADN; Reparación del ADN; Resistencia a Antineoplásicos; N-Metiltransferasa de Histona-Lisina/metabolismo; Proteínas Represoras/metabolismo; Animales; Línea Celular Tumoral; Proliferación Celular; Ensamble y Desensamble de Cromatina/efectos de los fármacos; Daño del ADN/efectos de los fármacos; Modelos Animales de Enfermedad; Resistencia a Antineoplásicos/genética; N-Metiltransferasa de Histona-Lisina/genética; Humanos; Ratones; Neoplasias/tratamiento farmacológico; Neoplasias/genética; Neoplasias/metabolismo; Neoplasias/patología; Pronóstico; Unión Proteica; Interferencia de ARN; ARN Interferente Pequeño/genética; Proteínas Represoras/genética; Transducción de Señal; Carga Tumoral; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Represoras / Daño del ADN / N-Metiltransferasa de Histona-Lisina / Resistencia a Antineoplásicos / Reparación del ADN / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article

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