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KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions.
Nakamura, Kohei; Nakayama, Kentaro; Ishibashi, Tomoka; Ishikawa, Noriyoshi; Ishikawa, Masako; Katagiri, Hiroshi; Minamoto, Toshiko; Sato, Emi; Sanuki, Kaori; Yamashita, Hitomi; Iida, Kouji; Sultana, Razia; Kyo, Satoru.
  • Nakamura K; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. kohei320@med.shimane-u.ac.jp.
  • Nakayama K; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. kn88@med.shimane-u.ac.jp.
  • Ishibashi T; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. tomoka19850314@gmail.com.
  • Ishikawa N; Department of Organ Pathology, Shimane University School of Medicine, Izumo 6938501, Japan. kanatomo@med.shimane-u.ac.jp.
  • Ishikawa M; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. pcbashi4@yahoo.co.jp.
  • Katagiri H; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. hkata@med.shimane-u.ac.jp.
  • Minamoto T; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. tokominmin@gmail.com.
  • Sato E; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. prettynanaone@gmail.com.
  • Sanuki K; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. kaorisanuki@gmail.com.
  • Yamashita H; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. memedasudasu1103@gmail.com.
  • Iida K; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. iida@med.shimane-u.ac.jp.
  • Sultana R; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. raeedahmed@yahoo.com.
  • Kyo S; Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan. satoruky@med.shimane-u.ac.jp.
Int J Mol Sci ; 17(5)2016 Apr 26.
Article en En | MEDLINE | ID: mdl-27128903
ABSTRACT
Ovarian low-grade serous carcinoma is thought to begin as a serous cystadenoma or adenofibroma that progresses in a slow stepwise fashion. Among the low-grade serous carcinomas, there is a high frequency of activating mutations in the KRAS or BRAF genes; however, it remains unclear as to how these mutations contribute to tumor progression. This is the first report to track the histopathological progression of serous adenofibroma to low-grade serous carcinoma. Each stage was individually analyzed by pathological and molecular genetic methods to determine what differences occur between the distinct stages of progression.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Cistadenocarcinoma Seroso / Proteínas ras / Proteínas Proto-Oncogénicas B-raf Límite: Female / Humans Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Cistadenocarcinoma Seroso / Proteínas ras / Proteínas Proto-Oncogénicas B-raf Límite: Female / Humans Idioma: En Año: 2016 Tipo del documento: Article