The Molecular Chaperone GRP78 Contributes to Toll-like Receptor 3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes.

Wei, Dahai; Li, Nan L; Zeng, Yanli; Liu, Baoming; Kumthip, Kattareeya; Wang, Tony T; Huo, Dezheng; Ingels, Jesse F; Lu, Lu; Shang, Jia; Li, Kui

Wei, Dahai; Li, Nan L; Zeng, Yanli; Liu, Baoming; Kumthip, Kattareeya; Wang, Tony T; Huo, Dezheng; Ingels, Jesse F; Lu, Lu; Shang, Jia; Li, Kui.

Wei D; From the Departments of Microbiology, Immunology and Biochemistry and.
Li NL; From the Departments of Microbiology, Immunology and Biochemistry and.
Zeng Y; the Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, China.
Liu B; From the Departments of Microbiology, Immunology and Biochemistry and.
Kumthip K; From the Departments of Microbiology, Immunology and Biochemistry and.
Wang TT; the SRI International, Harrisonburg, Virginia 22802, and.
Huo D; the Department of Public Health Sciences, University of Chicago, Chicago, Illinois 60637.
Ingels JF; Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163.
Lu L; Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163.
Shang J; the Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, China.
Li K; From the Departments of Microbiology, Immunology and Biochemistry and kli1@uthsc.edu.

J Biol Chem ; 291(23): 12294-309, 2016 Jun 03.

Article en En | MEDLINE | ID: mdl-27129228

Asunto(s)

Proteínas de Choque Térmico/metabolismo; Hepacivirus/inmunología; Hepatocitos/metabolismo; Inmunidad Innata; Receptor Toll-Like 3/metabolismo; Adulto; Línea Celular Tumoral; Células Cultivadas; Quimiocina CCL5/genética; Quimiocina CCL5/metabolismo; Quimiocina CXCL10/genética; Quimiocina CXCL10/metabolismo; Electroforesis en Gel Bidimensional; Chaperón BiP del Retículo Endoplásmico; Endosomas/metabolismo; Endosomas/virología; Femenino; Expresión Génica/efectos de los fármacos; Proteínas de Choque Térmico/genética; Hepacivirus/fisiología; Hepatitis C Crónica/genética; Hepatitis C Crónica/metabolismo; Hepatitis C Crónica/virología; Hepatocitos/efectos de los fármacos; Hepatocitos/virología; Interacciones Huésped-Patógeno; Humanos; Factor 3 Regulador del Interferón/genética; Factor 3 Regulador del Interferón/metabolismo; Lisosomas/metabolismo; Lisosomas/virología; Masculino; Microscopía Confocal; Persona de Mediana Edad; Poli I-C/farmacología; Interferencia de ARN; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Receptor Toll-Like 3/genética

Palabras clave

GRP78; Hepatitis C virus (HCV); RANTES; Toll-like receptor-3; chemokine; hepatocyte; innate immunity; interferon regulatory factor-3; interferon stimulated gene; molecular chaperone

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hepacivirus / Hepatocitos / Receptor Toll-Like 3 / Proteínas de Choque Térmico / Inmunidad Innata Tipo de estudio: Prognostic_studies Idioma: En Año: 2016 Tipo del documento: Article

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