Searching for the Chokehold of NRAS Mutant Melanoma.
J Invest Dermatol
; 136(7): 1330-1336, 2016 07.
Article
en En
| MEDLINE
| ID: mdl-27160069
ABSTRACT
Up to 18% of melanomas harbor mutations in the neuroblastoma rat-sarcoma homolog (NRAS). Yet, decades of research aimed to interfere with oncogenic RAS signaling have been largely disappointing and have not resulted in meaningful clinical outputs. Recent advances in disease modeling, structural biology, and an improved understanding of RAS cycling as well as RAS signaling networks have renewed hope for developing strategies to selectively block hyperactive RAS function. This review discusses direct and indirect blocking of activated RAS with a focus on current and potential future therapeutic approaches for NRAS mutant melanoma.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
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Proteínas Mutantes
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GTP Fosfohidrolasas
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Melanoma
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Proteínas de la Membrana
Límite:
Animals
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article