Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal.
Stem Cell Reports
; 6(6): 798-805, 2016 06 14.
Article
en En
| MEDLINE
| ID: mdl-27161363
ABSTRACT
Regeneration of vertebrate skeletal muscles requires satellite cells, a population of stem cells that are quiescent in normal conditions and divide, differentiate, and self-renew upon activation triggered by exercise, injury, and degenerative diseases. Satellite cell self-renewal is essential for long-term tissue homeostasis, and previous work has identified a number of external cues that control this process. However, little is known of the possible intrinsic control mechanisms of satellite cell self-renewal. Here, we show that quiescent satellite cells harbor a primary cilium, which is rapidly disassembled upon entry into the cell cycle. Contrasting with a commonly accepted belief, cilia reassembly does not occur uniformly in cells exiting the cell cycle. We found that primary cilia reassemble preferentially in cells committed to self-renew, and disruption of cilia reassembly causes a specific deficit in self-renewing satellite cells. These observations indicate that primary cilia provide an intrinsic cue essential for satellite cell self-renewal.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cilios
/
Músculo Esquelético
/
Células Satélite del Músculo Esquelético
/
Miofibrillas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article