Marine Biodiscovery Goes Deeper: Using In Vivo Bioassays Based on Model Organisms to Identify Biomedically Relevant Marine Metabolites.
Planta Med
; 82(9-10): 754-60, 2016 Jun.
Article
en En
| MEDLINE
| ID: mdl-27191583
ABSTRACT
Secondary metabolites from marine organisms are structurally diverse small molecules with high levels of bioactivity, and represent an underutilized resource for modern drug discovery. To facilitate the identification of drug-like marine metabolites, the significant potential of in vivo models of human disease - in particular those suitable for medium-throughput screening and bioassay-guided fractionation - should be explored in future marine biodiscovery efforts. Here, we explore the advantages of Caenorhabditis elegans, Drosophila, and zebrafish bioassays for marine biodiscovery, and review recent progress in using these in vivo models to identify bioactive marine metabolites.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Productos Biológicos
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Descubrimiento de Drogas
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Organismos Acuáticos
Límite:
Animals
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article