Infusion of human insulin-like growth factor I (IGF-I) into malnourished rats reduces hepatic IGF-I mRNA abundance.
Biochem Biophys Res Commun
; 160(2): 795-800, 1989 Apr 28.
Article
en En
| MEDLINE
| ID: mdl-2719698
ABSTRACT
To determine whether the serum level of IGF-I influences its hepatic synthesis through negative feedback regulation, we infused 200 micrograms/d of human IGF-I subcutaneously into young male rats eating either an energy-restricted or ad lib diet. In energy-restricted rats, a two-fold increase in serum IGF-I concentration produced a 41% increase in growth rate at the end of one week, and a 30% decrease in steady state hepatic IGF-I mRNA and 56% drop in serum GH at the end of two weeks. In ad lib fed rats, the increased serum IGF-I concentration neither enhanced growth rate nor significantly reduced hepatic IGF-I mRNA abundance or serum GH levels. These data suggest that the abundance of hepatic IGF-I mRNA in energy-restricted rats is controlled, in part, by serum IGF-I levels via negative feedback regulation.
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Banco de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
Somatomedinas
/
Factor I del Crecimiento Similar a la Insulina
/
Hígado
/
Trastornos Nutricionales
Límite:
Animals
Idioma:
En
Año:
1989
Tipo del documento:
Article