The efficacy of botulinum toxin for the treatment of trigeminal and postherpetic neuralgia: a systematic review with meta-analyses.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 122(1): 61-71, 2016 Jul.
Article
en En
| MEDLINE
| ID: mdl-27260275
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of a botulinum toxin type A (BoTN-A) in treating trigeminal neuralgia (TN) and postherpetic neuralgia (PHN). STUDYDESIGN:
Three databases were searched Medline, Web of Science, and Cochrane Library. The search was restricted to English-language randomized, placebo-controlled trials. Three review authors evaluated the cases for risk of bias.RESULTS:
Six studies were eligible for inclusion. Pooled results showed a difference in post-treatment pain intensity of -3.009 (95% confidence interval -4.566 to -1.453; P < .001) in favor of BoTN-A compared with placebo in managing TN or PHN. Of the six studies, five had unclear risk of bias, and one showed high risk.CONCLUSIONS:
Although the studies had unclear or high risk of bias, moderate evidence regarding the efficacy of BoTN-A in treating TN and PHN was found. BoTN-A might be an alternative treatment to those patients who are either unable to manage their pain medically or would like adjunct therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neuralgia del Trigémino
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Toxinas Botulínicas Tipo A
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Neuralgia Posherpética
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Fármacos Neuromusculares
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article