KOTMIN13, a Korean herbal medicine alleviates allergic inflammation in vivo and in vitro.
BMC Complement Altern Med
; 16: 169, 2016 Jun 06.
Article
en En
| MEDLINE
| ID: mdl-27267050
ABSTRACT
BACKGROUND:
The ethanol extract of KOTMIN13, composed of Inula japonica Flowers, Trichosanthes kirilowii Semen, Peucedanum praeruptorum Radix, and Allium macrostemon Bulbs, was investigated for its anti-asthmatic and anti-allergic activities.METHODS:
The anti-asthmatic effects of KOTMIN13 were evaluated on ovalbumin (OVA)-induced murine asthma model. Anti-allergic properties of KOTMIN13 in bone-marrow derived mast cells (BMMC) and passive cutaneous anaphylaxis (PCA) in vivo were also examined.RESULTS:
In asthma model, KOTMIN13 effectively suppressed airway hyperresponsiveness induced by aerosolized methacholine when compared to the levels of OVA-induced mice. KOTMIN13 treatment reduced the total leukocytes, eosinophil percentage, and Th2 cytokines in the bronchoalveolar lavage fluids in OVA-induced mice. The increased levels of eotaxin and Th2 cytokines in the lung as well as serum IgE were decreased by KOTMIN13. The histological analysis shows that the increased inflammatory cell infiltration and mucus secretion were also reduced. In addition, the degranulation and leukotriene C4 production were inhibited in BMMC with IC50 values of 3.9 µg/ml and 1.7 µg/ml, respectively. Furthermore, KOTMIN13 treatment attenuated mast-mediated PCA reaction.CONCLUSIONS:
These results demonstrate that KOTMIN13 has anti-asthmatic and anti-allergic effects in vivo and in vitro models.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
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Antiasmáticos
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Medicina de Hierbas
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Obstrucción de las Vías Aéreas
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Inflamación
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article