Pharmacokinetics of dilevalol in normotensive and hypertensive volunteers.
Am J Cardiol
; 63(19): 7I-11I, 1989 Jun 05.
Article
en En
| MEDLINE
| ID: mdl-2729127
ABSTRACT
Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific antagonism of beta 1- and beta 2-adrenergic receptors. Studies of dilevalol's pharmacokinetics in normotensive and hypertensive volunteers have demonstrated that (1) it is rapidly and well absorbed; (2) because of extensive first-pass metabolism its absolute oral bioavailability is about 12%; (3) its mean elimination half-life is 8 to 12 hours after administration of single oral or intravenous doses to normal volunteers, a value consistent with once-daily dosing; and (4) food does not appear to alter its bioavailability or pharmacokinetics.
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Banco de datos:
MEDLINE
Asunto principal:
Hipertensión
/
Labetalol
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Humans
Idioma:
En
Año:
1989
Tipo del documento:
Article