Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008-2013.
J Infect Dis
; 214(5): 732-8, 2016 09 01.
Article
en En
| MEDLINE
| ID: mdl-27302190
ABSTRACT
BACKGROUND:
Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3-7 geographically diverse sites in the United States since 2006.METHODS:
Over 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping.RESULTS:
In the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%-84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%-3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype.CONCLUSIONS:
Continued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Rotavirus
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Rotavirus
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Vacunas contra Rotavirus
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Genotipo
Tipo de estudio:
Risk_factors_studies
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Screening_studies
Límite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País como asunto:
America do norte
Idioma:
En
Año:
2016
Tipo del documento:
Article