Adolescent exposure to MDMA induces dopaminergic toxicity in substantia nigra and potentiates the amyloid plaque deposition in the striatum of APPswe/PS1dE9 mice.

Abad, Sonia; Ramon, Carla; Pubill, David; Camarasa, Jorge; Camins, Antonio; Escubedo, Elena

Abad, Sonia; Ramon, Carla; Pubill, David; Camarasa, Jorge; Camins, Antonio; Escubedo, Elena.

Abad S; Department of Pharmacology, Toxicology and Therapeutic Chemistry (Pharmacology Section) and Biomedicine Institute, University of Barcelona (IBUB), Spain.
Ramon C; Department of Pharmacology, Toxicology and Therapeutic Chemistry (Pharmacology Section) and Biomedicine Institute, University of Barcelona (IBUB), Spain.
Pubill D; Department of Pharmacology, Toxicology and Therapeutic Chemistry (Pharmacology Section) and Biomedicine Institute, University of Barcelona (IBUB), Spain.
Camarasa J; Department of Pharmacology, Toxicology and Therapeutic Chemistry (Pharmacology Section) and Biomedicine Institute, University of Barcelona (IBUB), Spain.
Camins A; Department of Pharmacology, Toxicology and Therapeutic Chemistry (Pharmacology Section) and Biomedicine Institute, University of Barcelona (IBUB), Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Spain. Electronic address: camins@ub.edu.
Escubedo E; Department of Pharmacology, Toxicology and Therapeutic Chemistry (Pharmacology Section) and Biomedicine Institute, University of Barcelona (IBUB), Spain.

Biochim Biophys Acta ; 1862(9): 1815-26, 2016 09.

Article en En | MEDLINE | ID: mdl-27344237

Asunto(s)

Cuerpo Estriado/efectos de los fármacos; Neuronas Dopaminérgicas/efectos de los fármacos; N-Metil-3,4-metilenodioxianfetamina/toxicidad; Placa Amiloide/inducido químicamente; Placa Amiloide/metabolismo; Sustancia Negra/efectos de los fármacos; Adolescente; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Animales; Cuerpo Estriado/metabolismo; Cuerpo Estriado/patología; Neuronas Dopaminérgicas/metabolismo; Humanos; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Mutantes; Ratones Transgénicos; Monoaminooxidasa/metabolismo; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; N-Metil-3,4-metilenodioxianfetamina/administración & dosificación; Estrés Oxidativo/efectos de los fármacos; Placa Amiloide/patología; Presenilina-1/genética; Presenilina-1/metabolismo; Proteínas Recombinantes de Fusión/genética; Proteínas Recombinantes de Fusión/metabolismo; Maduración Sexual; Sustancia Negra/metabolismo; Sustancia Negra/fisiología; Tirosina 3-Monooxigenasa/metabolismo

Palabras clave

3.4-Methylenedioxymethamphetamine; APPswe/PS1dE9 mice; Amyloid plaques; Dopaminergic dysfunction; Striatum

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sustancia Negra / N-Metil-3,4-metilenodioxianfetamina / Placa Amiloide / Cuerpo Estriado / Neuronas Dopaminérgicas Tipo de estudio: Prognostic_studies Límite: Adolescent / Animals / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article

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