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A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells.
Chen, Chih-Wei; Lee, Yueh-Lun; Liou, Jing-Ping; Liu, Yu-Hsiu; Liu, Chin-Wei; Chen, Tsai-Yun; Huang, Huei-Mei.
  • Chen CW; Neurosurgery Department, Chi Mei Medical Center, No. 901, Zhonghua Rd., Tainan, 710, Taiwan.
  • Lee YL; Department of Microbiology and Immunology, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Taipei, 11031, Taiwan.
  • Liou JP; School of Pharmacy, College of Pharmacy, Taipei Medical University, No. 250, Wuxing St., Taipei, 11031, Taiwan.
  • Liu YH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Taipei, 11031, Taiwan.
  • Liu CW; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Taipei, 11031, Taiwan.
  • Chen TY; Department of Internal Medicine, College of Medicine, National Cheng Kung University, No. 1, University Rd., Tainan, 701, Taiwan.
  • Huang HM; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Taipei, 11031, Taiwan. cmbhhm@tmu.edu.tw.
Apoptosis ; 21(9): 1008-18, 2016 09.
Article en En | MEDLINE | ID: mdl-27344662
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sulfonas / Tubulina (Proteína) / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Apoptosis / Moduladores de Tubulina / Mesilato de Imatinib / Indoles / Antineoplásicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sulfonas / Tubulina (Proteína) / Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Apoptosis / Moduladores de Tubulina / Mesilato de Imatinib / Indoles / Antineoplásicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Año: 2016 Tipo del documento: Article