SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome.
Pharmacogenomics
; 17(11): 1227-1233, 2016 07.
Article
en En
| MEDLINE
| ID: mdl-27377607
ABSTRACT
AIM:
of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. PATIENTS &METHODS:
66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution.RESULTS:
Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity.CONCLUSION:
The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Corticoesteroides
/
Oxidorreductasas actuantes sobre Donantes de Grupos Sulfuro
/
Síndrome Nefrótico
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2016
Tipo del documento:
Article