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SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome.
Turolo, Stefano; Edefonti, Alberto; Lepore, Marta; Ghio, Luciana; Cuzzoni, Eva; Decorti, Giuliana; Pasini, Andrea; Materassi, Marco; Malaventura, Cristina; Pugliese, Fabrizio; Montini, Giovanni.
  • Turolo S; Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
  • Edefonti A; Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
  • Lepore M; Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
  • Ghio L; Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
  • Cuzzoni E; Università degli Studi di Trieste Dipartimento di Scienze della Vita, Trieste, Friuli-Venezia Giulia, Italy.
  • Decorti G; Università degli Studi di Trieste Dipartimento di Scienze della Vita, Trieste, Friuli-Venezia Giulia, Italy.
  • Pasini A; Università degli Studi di Bologna Azienda Ospedaliera Sant/'Orsola-Malpighi, Bologna, Emilia-Romagna, Italy.
  • Materassi M; Ospedale Pediatrico Meyer Firenze, Toscana, Italy.
  • Malaventura C; Università degli Studi di Ferrara, Medical Science Ferrara, Emilia-Romagna, Italy.
  • Pugliese F; Agenzia sanitaria e sociale regionale Regione Emilia-Romagna, Ravenna, Emilia-Romagna, Italy.
  • Montini G; Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
Pharmacogenomics ; 17(11): 1227-1233, 2016 07.
Article en En | MEDLINE | ID: mdl-27377607
ABSTRACT

AIM:

of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. PATIENTS &

METHODS:

66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution.

RESULTS:

Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity.

CONCLUSION:

The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.
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Banco de datos: MEDLINE Asunto principal: Corticoesteroides / Oxidorreductasas actuantes sobre Donantes de Grupos Sulfuro / Síndrome Nefrótico Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article
Search on Google
Imprimir
XML
PubMed Links

Banco de datos: MEDLINE Asunto principal: Corticoesteroides / Oxidorreductasas actuantes sobre Donantes de Grupos Sulfuro / Síndrome Nefrótico Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article