Clinical profile and in-hospital outcome of Caucasian patients with takotsubo syndrome and right ventricular involvement.
Int J Cardiol
; 219: 455-61, 2016 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-27387098
ABSTRACT
AIM:
To determine the prevalence, clinical characteristics, in-hospital course and determinants of major adverse events in a cohort of Caucasian patients with Takotsubo syndrome (TTS) and right ventricular involvement (RVi), regardless of left ventricular variant forms. METHODS ANDRESULTS:
The study population consisted of 424 patients (mean age 69.1±11.5years; female 92.2%) with a diagnosis of TTS divided into two groups according to the presence or absence of RVi. RVi patients (n=57; 13.4%) showed a higher prevalence of comorbidities, especially respiratory diseases (p=0.011), and a higher Charlson comorbidity index (CCI; p=0.006) than non-RVi patients. In-hospital major adverse events (acute heart failure, cardiogenic shock and death) occurred more frequently in RVi patients (p<0.001). Heart rate and CCI, along with the echocardiographic parameters of wall motion score index, E/e' ratio, tricuspid annular plane systolic excursion (TAPSE) and systolic pulmonary artery pressure (sPAP) were associated with adverse in-hospital outcome. At multivariate analysis, CCI (HR 1.871; 95% CI 1.202-2.912; p=0.006), sPAP (HR 1.059; 95% CI 1.016-1.104; p=0.007) and TAPSE (HR 0.728; 95% CI 0.619-0.855; p<0.001) were independent correlates of the composite outcome in patients with RVi.CONCLUSION:
Patients with RVi are characterized by distinct clinical profile and should undergo closely clinical and echocardiographic monitoring. The presence of echocardiographic signs of right ventricular failure along with substantial comorbidities burden identify a cohort at higher risk of in-hospital major adverse cardiovascular events.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Mortalidad Hospitalaria
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Disfunción Ventricular Derecha
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Población Blanca
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Cardiomiopatía de Takotsubo
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2016
Tipo del documento:
Article