Arginine and Caries Prevention: A Systematic Review.
Caries Res
; 50(4): 383-93, 2016.
Article
en En
| MEDLINE
| ID: mdl-27403876
ABSTRACT
OBJECTIVES:
To evaluate the available evidence that the use of arginine-containing dental care products prevents the development of new caries lesions and the progression of existing lesions. SEARCHMETHODS:
We performed a systematic literature search of databases including PubMed, the Cochrane Library and EMBASE. SELECTION CRITERIA We selected randomized controlled trials of treatment with arginine in fluoride-containing dental products measuring dental caries incidence or progression in children, adults and elderly subjects. DATA COLLECTION ANDANALYSIS:
Two review authors independently assessed trials for risk of bias and evaluated overall study quality using the GRADE classification. MAINRESULTS:
Due to conflicts of interest and weak transferability to Swedish conditions, no conclusions can be drawn from studies on the effects of arginine-fluoride toothpaste in children. Arginine-containing toothpaste costs about 40% more than basic fluoride toothpaste; to determine whether it is more cost-effective, the higher cost must be considered in relation to any additional caries-preventive effect. The literature review also disclosed some questionable research ethics in several of the studies, the children in the control group used non-fluoride toothpaste. Toothpaste without fluoride is not as effective against dental caries as the standard treatment - fluoride toothpaste - which has a well-documented effect. This contravenes the fundamental principles of research ethics.CONCLUSION:
At present there is insufficient evidence in support of a caries-preventive effect for the inclusion of arginine in toothpastes. More rigorous studies, and studies which are less dependent on commercial interests, are required.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Arginina
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Pastas de Dientes
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Cariostáticos
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Caries Dental
Tipo de estudio:
Clinical_trials
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Health_economic_evaluation
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Incidence_studies
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Prognostic_studies
/
Systematic_reviews
Límite:
Adolescent
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Adult
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Aged
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Child
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article