Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy.
Int J Mol Sci
; 17(7)2016 Jul 13.
Article
en En
| MEDLINE
| ID: mdl-27420051
ABSTRACT
Cell fusion occurs in development and in physiology and rarely in those settings is it associated with malignancy. However, deliberate fusion of cells and possibly untoward fusion of cells not suitably poised can eventuate in aneuploidy, DNA damage and malignant transformation. How often cell fusion may initiate malignancy is unknown. However, cell fusion could explain the high frequency of cancers in tissues with low underlying rates of cell proliferation and mutation. On the other hand, cell fusion might also engage innate and adaptive immune surveillance, thus helping to eliminate or retard malignancies. Here we consider whether and how cell fusion might weigh on the overall burden of cancer in modern societies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Transformación Celular Neoplásica
/
Sistema Inmunológico
/
Neoplasias
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article