Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase.

Sui, Xuewu; Zhang, Jianye; Golczak, Marcin; Palczewski, Krzysztof; Kiser, Philip D

Sui, Xuewu; Zhang, Jianye; Golczak, Marcin; Palczewski, Krzysztof; Kiser, Philip D.

Sui X; From the Department of Pharmacology, School of Medicine, Case Western Reserve University and.
Zhang J; From the Department of Pharmacology, School of Medicine, Case Western Reserve University and.
Golczak M; From the Department of Pharmacology, School of Medicine, Case Western Reserve University and.
Palczewski K; From the Department of Pharmacology, School of Medicine, Case Western Reserve University and kxp65@case.edu.
Kiser PD; From the Department of Pharmacology, School of Medicine, Case Western Reserve University and Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106 pdk7@case.edu.

J Biol Chem ; 291(37): 19401-12, 2016 09 09.

Article en En | MEDLINE | ID: mdl-27453555

Asunto(s)

Proteínas Bacterianas/química; Dioxigenasas/química; Hierro/química; Synechocystis/enzimología; Sustitución de Aminoácidos; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Catálisis; Dominio Catalítico; Dioxigenasas/genética; Dioxigenasas/metabolismo; Hierro/metabolismo; Mutación Missense; Synechocystis/genética

Palabras clave

Leber congenital amaurosis; RPE65; enzyme mutation; metalloenzyme; non-heme iron; regioselectivity; retinal; rhodopsin; site-directed mutagenesis; x-ray crystallography

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Synechocystis / Dioxigenasas / Hierro Idioma: En Año: 2016 Tipo del documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Synechocystis / Dioxigenasas / Hierro Idioma: En Año: 2016 Tipo del documento: Article