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Release of PACAP-38 in episodic cluster headache patients - an exploratory study.
Tuka, Bernadett; Szabó, Nikoletta; Tóth, Eszter; Kincses, Zsigmond Tamás; Párdutz, Árpád; Szok, Délia; Körtési, Tamás; Bagoly, Teréz; Helyes, Zsuzsanna; Edvinsson, Lars; Vécsei, László; Tajti, János.
  • Tuka B; Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary.
  • Szabó N; MTA-SZTE Neuroscience Research Group, Semmelweis u. 6, Szeged, H-6725, Hungary.
  • Tóth E; Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary.
  • Kincses ZT; Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary.
  • Párdutz Á; Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary.
  • Szok D; Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary.
  • Körtési T; Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary.
  • Bagoly T; Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary.
  • Helyes Z; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Szigeti u. 12, Pécs, H-7624, Hungary.
  • Edvinsson L; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Szigeti u. 12, Pécs, H-7624, Hungary.
  • Vécsei L; János Szentágothai Research Center, University of Pécs, Ifjúság útja 20, Pécs, H-7624, Hungary.
  • Tajti J; MTA-PTE NAP B Pain Research Group, University of Pécs, Szigeti u. 12, Pécs, H-7624, Hungary.
J Headache Pain ; 17(1): 69, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27475101
BACKGROUND: Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH (ECH). Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls (n = 9). Plasma PACAP-38-like immunoreactivity (LI) was measured with specific and sensitive radioimmunoassay. FINDINGS: Significantly lower plasma PACAP-38-LI was detected in the inter-bout period of ECH patients than in healthy controls. However, PACAP-38 was significantly elevated in the plasma during CH attacks as compared to the inter-bout phase in the same subjects (n = 5). CONCLUSIONS: This exploratory study suggests that PACAP-38 may be released during the attacks of ECH. Further patients and long-term follow-up are necessary to reveal its function.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cefalalgia Histamínica / Polipéptido Hipofisario Activador de la Adenilato-Ciclasa Límite: Adult / Humans / Male / Middle aged Idioma: En Año: 2016 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cefalalgia Histamínica / Polipéptido Hipofisario Activador de la Adenilato-Ciclasa Límite: Adult / Humans / Male / Middle aged Idioma: En Año: 2016 Tipo del documento: Article