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Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.
Smaill, Jeff B; Gonzales, Andrea J; Spicer, Julie A; Lee, Helen; Reed, Jessica E; Sexton, Karen; Althaus, Irene W; Zhu, Tong; Black, Shannon L; Blaser, Adrian; Denny, William A; Ellis, Paul A; Fakhoury, Stephen; Harvey, Patricia J; Hook, Ken; McCarthy, Florence O J; Palmer, Brian D; Rivault, Freddy; Schlosser, Kevin; Ellis, Teresa; Thompson, Andrew M; Trachet, Erin; Winters, R Thomas; Tecle, Haile; Bridges, Alexander.
  • Smaill JB; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Gonzales AJ; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Spicer JA; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Lee H; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Reed JE; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Sexton K; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Althaus IW; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Zhu T; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Black SL; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Blaser A; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Denny WA; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Ellis PA; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Fakhoury S; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Harvey PJ; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Hook K; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • McCarthy FO; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Palmer BD; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Rivault F; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Schlosser K; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Ellis T; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Thompson AM; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Trachet E; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
  • Winters RT; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Tecle H; Pfizer Global Research and Development, Michigan Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan 48105-1047, United States.
  • Bridges A; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland , Private Bag 92019, Auckland 1142, New Zealand.
J Med Chem ; 59(17): 8103-24, 2016 09 08.
Article en En | MEDLINE | ID: mdl-27491023
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinas / Quinazolinas / Morfolinas / Quinazolinonas / Receptores ErbB / Antineoplásicos Tipo de estudio: Prognostic_studies Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinas / Quinazolinas / Morfolinas / Quinazolinonas / Receptores ErbB / Antineoplásicos Tipo de estudio: Prognostic_studies Idioma: En Año: 2016 Tipo del documento: Article