Evaluation and characterization of thyroid-disrupting activities in soil samples along the Second Songhua River, China.
Ecotoxicol Environ Saf
; 133: 475-80, 2016 Nov.
Article
en En
| MEDLINE
| ID: mdl-27526021
ABSTRACT
In this study, a recombinant thyroid receptor (TR) gene yeast assay combined with Monte Carlo simulation were used to evaluate and characterize soil samples collected from Jilin (China) along the Second Songhua River, for their ant/agonist effect on TR. No TR agonistic activity was found in soils, but many soil samples exhibited TR antagonistic activities, and the bioassay-derived amiodarone hydrochloride equivalents, which was calculated based on Monte Carlo simulation, ranged from not detected (N.D.) to 35.5µg/g. Hydrophilic substance fractions were determined to be the contributors to TR antagonistic activity in these soil samples. Our results indicate that the novel calculation method is effective for the quantification and characterization of TR antagonists in soil samples, and these data could provide useful information for future management and remediation efforts for contaminated soils.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Suelo
/
Contaminantes del Suelo
/
Antitiroideos
/
Glándula Tiroides
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Receptores de Hormona Tiroidea
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Ríos
/
Disruptores Endocrinos
Tipo de estudio:
Evaluation_studies
/
Health_economic_evaluation
País como asunto:
Asia
Idioma:
En
Año:
2016
Tipo del documento:
Article