The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity.
Int J Mol Sci
; 17(8)2016 Aug 05.
Article
en En
| MEDLINE
| ID: mdl-27527162
ABSTRACT
In humans, the ribonuclease A (RNase A) superfamily contains eight different members that have RNase activities, and all of these members are encoded on chromosome 14. The proteins are secreted by a large variety of different tissues and cells; however, a comprehensive understanding of these proteins' physiological roles is lacking. Different biological effects can be attributed to each protein, including antiviral, antibacterial and antifungal activities as well as cytotoxic effects against host cells and parasites. Different immunomodulatory effects have also been demonstrated. This review summarizes the available data on the human RNase A superfamily and illustrates the significant role of the eight canonical RNases in inflammation and the host defence system against infections.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ribonucleasa Pancreática
/
Familia de Multigenes
/
Inmunidad Innata
Límite:
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article