A systematic review and meta-analysis of acupuncture for improving learning and memory ability in animals.
BMC Complement Altern Med
; 16(1): 297, 2016 Aug 19.
Article
en En
| MEDLINE
| ID: mdl-27543143
ABSTRACT
BACKGROUND:
Memory loss is the most prominent symptoms of brain aging, but there is currently no evidence-based treatment strategy. Acupuncture has been widely used in China and the effectiveness for improving learning and memory has been mentioned in previous studies. We conducted this systematic review and meta-analysis to evaluate the effectiveness of acupuncture for improving learning and memory in animal experiments.METHODS:
We searched Pubmed, Embase, Ovid Medline(R), the China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP) and Wanfang data Information Site to collect studies published up to December 2015. Study quality for each included article was evaluated according to the CAMARADES 10-item checklist. Outcome measure is Morris water maze. A meta-analysis was conducted according to the Cochrane systematic review method by using RevMan 5.3 software.RESULTS:
Forty-two studies involving 944 animals were included. The quality score of the studies ranged from 2 to 8, with a mean of 5.3. Meta-analysis results showed that 24 studies reported significant effect of acupuncture for decreasing escape latency (-3.00, 95 % CI -3.78 ~ -2.23, P < 0.00001), 14 studies reported significant effect of acupuncture for increasing frequency of cross platform (2.57, 95 % CI 1.92 ~ 3.22, P < 0.00001), and 7 studies reported significant effect of acupuncture for increasing time in target quadrant (2.00, 95 % CI 1.10 ~ 2.91, P < 0.00001) compared with the control group.CONCLUSIONS:
These findings show acupuncture has a potential role in improving learning and memory ability in animal models, suggesting it as a candidate therapy for memory loss of aged brain.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Terapia por Acupuntura
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Aprendizaje por Laberinto
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Memoria
Tipo de estudio:
Prognostic_studies
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Systematic_reviews
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article