Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide.

Zhang, Liqing; Zhang, Zhangang; Fu, Yan; Yang, Pin; Qin, Zhenxia; Chen, Yongjun; Xu, Ying

Zhang, Liqing; Zhang, Zhangang; Fu, Yan; Yang, Pin; Qin, Zhenxia; Chen, Yongjun; Xu, Ying.

Zhang L; Department of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Zhang Z; Department of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Fu Y; Department of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Yang P; Department of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Qin Z; Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Chen Y; Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Guangzhou 510006, China.
Xu Y; Department of Physiology, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: ying6122003@aliyun.com.

Neuropharmacology ; 110(Pt A): 503-518, 2016 11.

Article en En | MEDLINE | ID: mdl-27543415

Asunto(s)

Acroleína/análogos & derivados; Trastornos de la Memoria/tratamiento farmacológico; Microglía/efectos de los fármacos; Fármacos Neuroprotectores/farmacología; Óxido Nítrico Sintasa de Tipo II/metabolismo; Nootrópicos/farmacología; Acroleína/farmacología; Animales; Supervivencia Celular/efectos de los fármacos; Supervivencia Celular/fisiología; Células Cultivadas; Corteza Cerebral; Modelos Animales de Enfermedad; Estabilidad de Enzimas/efectos de los fármacos; Escherichia coli; Lipopolisacáridos; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Masculino; Trastornos de la Memoria/enzimología; Trastornos de la Memoria/inmunología; Trastornos de la Memoria/patología; Ratones Endogámicos ICR; Microglía/enzimología; Microglía/patología; Óxido Nítrico/metabolismo; ARN Mensajero/metabolismo; Distribución Aleatoria; Ratas Sprague-Dawley

Palabras clave

MEK1/2-ERK1/2 signaling pathway; Memory impairment; Microglial activation; Neuroinflammation; Trans-cinnamaldehyde; iNOS mRNA stability

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acroleína / Microglía / Nootrópicos / Fármacos Neuroprotectores / Óxido Nítrico Sintasa de Tipo II / Trastornos de la Memoria Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article

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